Moreover, recent results of the prospective randomized AMLSG 09-09 Phase III study in NPM1-positive AML patients have not shown a difference in EFS from addition of GO to induction therapy with IDA, ARA-C, etoposide, and all-trans-retinoic acid, mainly for a higher early death rate in the GO arm [54]. The gene discussed is NPM1; the disease is acute myeloid leukemia.