Using the fluorescence-activated cell scanning, Julich-Haertel et al. identified a subgroup of EVs, the EpCAM+ asialoglycoprotein receptor 1+ (ASGPR1)+ EVs, which is capable of distinguishing HCC from cirrhosis with an AUC of 0.73 [13]. Here, EPCAM is linked to hepatocellular carcinoma.