AKT1 and hepatocellular carcinoma: Similarly, other oncogenic proteins in HCC-derived EVs, MET and caveolins (CAV1 and CAV2), are also involved in the PI3K/Akt and mitogen-activated protein kinase (MAPK)/extracellular-signal-regulated kinase (ERK) pathways to promote migration and invasion of immortalized hepatocytes [98].