miR-32-5p and miR-92a-3p in HCC-derived EVs suppress phosphatase and tensin homolog (PTEN) and activate the phosphoinositide 3-kinase (PI3K)/Akt (Protein kinase B, PKB) pathway to induce EMT and metastasis in vivo [66,90]. Here, AKT1 is linked to hepatocellular carcinoma.