Using the fluorescence-activated cell scanning, Julich-Haertel et al. identified a subgroup of EVs, the EpCAM+ asialoglycoprotein receptor 1+ (ASGPR1)+ EVs, which is capable of distinguishing HCC from cirrhosis with an AUC of 0.73 [13]. This evidence concerns the gene ASGR1 and hepatocellular carcinoma.