In contrast to MYBPC1, which is strongly implicated in human disease, the role of fast skeletal muscle myosin binding protein C2 (MYBPC2) in DA is less clear, as there is only a single report of MYBPC2 variants in DA patients in whom other known arthrogryposis gene variants were also observed, suggesting a possible role as a modifier [18]. This evidence concerns the gene MYBPC2 and arthrogryposis.