Possibly due to the small sample size, besides positive ER status and normal SSc pattern at videocapillaroscopy, no statistically significant associations were observed between any oncological characteristic (pathological stage, Mib1 level, or ER expression) and rheumatological features such as skin extension of the disease, presence of skin ulcers, calcinosis, teleangectasia, and gastro-intestinal and kidney involvement. The gene discussed is MIB1; the disease is Skin ulcer.