No other statistically significant associations were observed between BC pathological stage, Mib1 level or ER expression, and skin extension of the disease, the presence of skin ulcers, calcinosis, teleangectasia, gastro-intestinal and kidney involvement, interstitial lung disease (at HR-CT), FVC and DLCO SB values, echocardiographic assessment of PAH with PAPs measurement, ECG abnormalities, SSc pattern at videocapillaroscopy, and autoantibody profile (ANA, ACA, ANoA, and Anti-Scl-70) (Table 3). This evidence concerns the gene FDXR and Skin ulcer.