Indeed, they induce the expansion of cytotoxic T lymphocytes; reduction of immunosuppressive cells, including suppressor cells derived from CD38+ myeloid, CD38+ regulatory B cells and a CD38+ regulatory T subpopulation (CD4+ CD25+ CD127dim), to promote T cell activity against MM cells; and increased T cell repertoire clonality, reduction of NK cells, and downregulation of CD38 on target cells [14,36]. The gene discussed is CD38; the disease is Miyoshi myopathy.