In contrast, in the infected Gal-3 KO mice, we observed upregulation of chia1, fcnb, sftpd, and st3gal5. Additionally, in the downregulated group, PRRs responsive to mannose/chitin (cd207, cd209a) and inflammation (csf2, myd88, ptgs2) were commonly regulated in WT and Gal-3 KO mice with cryptococcosis (Figure 2). Here, LGALS3 is linked to cryptococcosis.