CARD9 and fungal infectious disease: These results suggest that fungal infection by C. neoformans in WT and Gal-3 KO mice relative to their control groups promotes upregulation of mannose receptor, C, type1 (mrc1) and chemokine (C-C motif) receptor 5 (ccr5) and downregulation of card9, cd209a, colec12, fos, ikbkb, jun, and nptx1 in the three analyzed organs (Figure 3A).