The gene profile analysis of innate immunity in the lungs, spleen, and brain during infection by C. neoformans, suggests that Gal-3 is involved in the upregulation of PRRs responsive to β-glucan and mannose/chitin (clec7a and mrc1), as well as the genes related to inflammation (cxcl1, cxcl9, cxcl10, ccr1, ccr5, il-6), and phagocytosis (sftpd). This evidence concerns the gene LGALS3 and infection.