It is also involved in the downregulation of cd209a and Fc receptors, proinflammatory cytokines il-1β and il-12b, as well as the genes involved in signal transduction, such as tyrosine kinase (syk) and myd88. Therefore, we hypothesized that Gal-3 might play an important role in innate immunity in the development of effective antifungal immune response against cryptococcosis and may potentially influence the adaptive immune response as well. Here, LGALS3 is linked to cryptococcosis.