IL12B and cryptococcosis: It is also involved in the downregulation of cd209a and Fc receptors, proinflammatory cytokines il-1β and il-12b, as well as the genes involved in signal transduction, such as tyrosine kinase (syk) and myd88. Therefore, we hypothesized that Gal-3 might play an important role in innate immunity in the development of effective antifungal immune response against cryptococcosis and may potentially influence the adaptive immune response as well.