Hypothesizing that alterations to the relative Th1/Th2 balance of immune responses in association with T2D may contribute to the reduced shedding indicated, we continued by investigating the potential contribution of the IL-6/TNF-α ratio—a ratio associated with Th2-biased immune responses [29]—to the lower levels of plasma Sdc-1 detected in T2D patients. This evidence concerns the gene TNF and type 2 diabetes mellitus.