IFNG and type 2 diabetes mellitus: Furthermore, the trend towards a positive correlation between IFN-γ and the adventitial Sdc-1 expression in T2D patients may be related to the fact that shed Sdc-1 in plasma binds and inhibits IFN-γ, resulting in less-detected IFN-γ under the conditions of increased shedding and a low Sdc-1 tissue expression [49,50].