GLP1R and type 2 diabetes mellitus: As GLP-1 has been shown to regulate processes that control Sdc-1 expression [23,26,27,28] and as the fpGLP-1 levels were upregulated in patients with aortic valve pathology in association with T2D [30] (Figure 3A), we investigated the possible contribution of fpGLP-1 to the increased adventitial expression of Sdc-1 in T2D patients.