In contrast, the expression of both SLC22A1 (encoding OCT1) and SLC22A2 (encoding OCT2) is down-regulated in human centroblastic lymphoma (CL) and DLBCL [52,58], while CHKB expression is significantly decreased in human BL and HL [53,54,58]. This evidence concerns the gene SLC22A1 and diffuse large B-cell lymphoma.