MYC and diffuse large B-cell lymphoma: Of particular interest, MYC, an oncoprotein frequently elevated or activated in many B cell malignancies, acts as a positive regulator of choline metabolism in DLBCL by inducing the transcriptional up-regulation of phosphate cytidylyltransferase 1 choline-α (PCYT1A) (also known as CTP:phosphocholine cytidylyltransferase-α, CCT), the rate-limiting enzyme of the Kennedy pathway of PC biosynthesis [48] (Figure 2).