In light of the evidence that HDAC inhibitors induce CHKα up-regulation in human DLBCL and solid tumors [17,83], it would be interesting to test if CHKα overexpression is caused by epigenetic alterations in various T cell malignancies and if HDAC inhibitors induce CHKα up-regulation in malignant T cells. Here, CHKA is linked to diffuse large B-cell lymphoma.