Corroborating the human evidence, specific deletion of the Traf3 gene in B lymphocytes (B-Traf3−/−) causes remarkably prolonged survival of mature B cells independent of BAFF, which eventually leads to spontaneous development of splenic MZL and B1 lymphoma in mice, demonstrating that TRAF3 is a tumor suppressor in B cells [66,67,68,69]. Here, TRAF3 is linked to neoplasm.