Indeed, the identification of protein–protein interaction networks of proteins containing aberrantly regulated AS exons showed the presence of numerous direct interactions with key players of breast tumorigenesis, such as the RHOA GTPase (that interacts with DIAPH1), the AKT activator PIK3CA (that is encoded by the second most frequently mutated gene in breast cancer) [55], or the oncogenic protein kinase Cι (encoded by PRKCI gene). Here, PIK3CA is linked to breast carcinoma.