In addition, both mRNA and amyloid-beta precursor binding protein 2 (APBB2), which is known to interact with the cytoplasmic domain of APP and allow its cleavage by γ-secretase [48], were significantly upregulated by approximately 2.5-fold, thus contributing to the increased generation of Aβ 42 in NPC cells [49]. This evidence concerns the gene APP and nasopharyngeal carcinoma.