Leptin can regulate angiogenesis via VEGF and IL-6, and fibroblast growth factor (FGF) 2, suppresses apoptosis through a Bcl-2-dependent mechanism and acts as a mitogen or migration factor for many different cell types, including cancer cells, as well as sustaining the recruitment of monocytes and macrophages, that allow leptin to shape the TME [149]. The gene discussed is VEGFA; the disease is cancer.