RYR2 and catecholaminergic polymorphic ventricular tachycardia: Missense mutations in RYR2, the gene encoding the cardiac ryanodine receptor type 2 (RyR2), are the major cause of the CPVT dominant form with detection of a RYR2 mutation in 60 to 65% of patients, including a high rate of de novo mutations [9,10,11,12,13].