RYR2 and catecholaminergic polymorphic ventricular tachycardia: The typical CPVT RyR2 mutations render RyR2 channels more prone to spontaneous Ca2+ release resulting in Ca2+ waves that trigger membrane depolarizations, premature ventricular beats (PVB), and polymorphic ventricular tachycardia (PVT) during physical activity or emotional stress [18,25].