In this setting, oral squamous cell carcinoma induced by painting with 0.5% 7,12-dimethylbenz[a]anthracene-induced (DMBA-induced) in hamster buccal pouch (HBP) (male golden Syrian hamsters) evidenced over-expression of the mutant form of p53 and Bcl-2 coupled with decreased expression of wild type p53 and Bax [17,50]. The gene discussed is TP53; the disease is oral cavity squamous cell carcinoma.