Based on the above-mentioned observations, it seems evident that ginger derivatives interfere with the proliferation and cell cycle of cancer cells by arresting cell cycle in G0/G1 or G2/M phases, by significantly reducing the cyclin D1 gene expression, by upregulating p21 expression, and by inhibiting PI3K/AKT/mTOR and STAT3. This evidence concerns the gene CCND1 and cancer.