AKT1 and endometrial cancer: Carino et al. conducted research on endometrial cancer cell lines (Ishikawa, SK-UT2, An3Ca, primary EEC) and benign endometrium (HES) using JAK/STAT, MAPK/ERK, PI3K/AKT, and mTOR inhibitors to determine how leptin-mediated signaling affected the level of pro-inflammatory and pro-angiogenic cytokines.