ARG1 and myelodysplastic syndrome: Furthermore, CD33 knockdown reduces IL-10 and TGF-β secretion and ARG1 activity, therefore downregulating MDSC immunosuppressive activity; moreover, the induction of MDSCs’ maturation, by either all-trans-retinoic acid treatment or active immunoreceptor tyrosine-based activation motif-bearing (ITAM-bearing) adapter protein (DAP12) interruption, rescues the hematologic phenotype of MDS [153,154].