In addition, high-risk MDS-derived MDSCs exhibit higher activated activator of transcription (STAT)3 and C-C chemokine receptor type (CCR)2 expression, whereas STAT3 pathway targeting decreases ARG1 expression in MDSCs and partially revokes reduced expression levels of effector molecules in CD8+ T lymphocytes [155]. Here, ARG1 is linked to myelodysplastic syndrome.