Milgrom et al. [110] reported the case of a woman diagnosed at the age of 26 with primary multifocal ON, in context of complex thrombophilia (FV Leiden heterozygosity, C677T MTHFR homozygosity, and hypofibrinolytic 4G4G homozygosity for the PAI-1 gene). This evidence concerns the gene F5 and Rare hereditary thrombophilia.