KRAS and neoplasm: Among patient-related features, clinicians should consider age, performance status, comorbidities, patients’ preferences and values as well as life expectancy [12,13,14], while among tumor-related characteristics, primary tumor sidedness (i.e., right vs. left colon) [15,16,17,18] and molecular profile (i.e., KRAS-mutated vs. KRAS wild-type) [19,20] play a key (and growing) role.