However, the authors of the study reported a lower objective response rate (ORR) to anti-EGFR therapies in HER2-amplified CRC patients and relied on a strong biological rationale, as HER2 overexpression represents an alternative pathway to obviate EGFR signaling in tumorigenesis and/or in tumor progression [101,120]. This evidence concerns the gene EGFR and colorectal carcinoma.