Among these, 12 RBPs (RPS3, RBM22, EIF2S1, DHX8, RBM8A, UPF1, YBX1, SNRPE, SF3A1, U2AF1, SUPT6H, EIF3G) promoted tumor cell growth without expressional changes in any cancer cell line (Table 2). The gene discussed is UPF1; the disease is cancer.