Our microarray analysis using epithelial-like tumor cell lines showed significant differences in 12 RBPs between cancer and non-cancerous cells, whereas our in silico database analysis showed that two RBPs (RPS3, SNRPE), eight RBPs (RBM22, EIF2S1, RBM8A, UPF1, YBX1, SNRPE, DHX8, SF3A1) and two RBPs (SNRPE, SF3A1) were upregulated in colorectal, pancreatic and esophageal cancer tissue, respectively (Figure S1). The gene discussed is YBX1; the disease is cancer.