Eif2s1(tm1RjK) mice, in which Ser51 of eukaryotic initiation factor 2 subunit alpha (eIF2α, the homolog of EIF2S1) is mutated, do not survive after birth due to hypoglycemia associated with defective gluconeogenesis caused by a homozygous mutation [35]. This evidence concerns the gene EIF2A and Hypoglycemia.