RSTS share clinical overlap with other chromatinopathies, particularly with other disorders caused by aberrant histone acetylation such as Floating Harbor syndrome (FLHS, OMIM #136140) (mutations in the SRCAP gene encoding an SNF2-related chromatin remodeler, coactivator of CBP-mediated transcription), Genitopatellar (GTPTS, OMIM #606170) and Bieseker-Young-Simpson (SBBYSS #603736) syndromes (mutations in KAT6B gene encoding the Lysine acetyltransferase 6B, part of the H3 acetyltransferase complex). This evidence concerns the gene KAT6B and Floating-Harbor syndrome.