ASXL1 is a reader and is responsible for Bohring-Opitz syndrome (BOPS, OMIM #605039) and KMT2A et KMT2D (lysine methyltransferase 2A and 2D) are writers just like CREBBP et EP300 and are responsible for Wiedemann-Steiner (WDSTS, OMIM #605130) and Kabuki (KS, OMIM #147920, #300867) syndromes respectively. This evidence concerns the gene EP300 and Bohring-Opitz syndrome.