Another sepsis study finds that melatonin treatment reverses NLRP3 activation in kidneys of septic rats, coupled with a melatonin-induced rise in mitochondrial superoxide dismutase (SOD2), suggesting that suppression of excess ROS might play a role in melatonin’s effect on NLRP3 inflammasome activation [91]. This evidence concerns the gene NLRP3 and Sepsis.