NFKB1 and spinal cord injury: Melatonin also diminishes trauma-induced NLRP3 activity in spinal cord injury (SCI) by downregulation of TLR4/NF-κB and NOX2/TXNIP [80,81] and traumatic brain injury (TBI) by NF-κB inhibition, prevention of HMGB1 nuclear export, and reduction in necroptosis through A20 [82].