EGFR and lung adenocarcinoma: Given the significant results of the FLAURA trial and the emergence of T790M mutations during treatment with early generation EGFR TKI, osimertinib is considered the standard of care as a frontline therapy in EGFR-mutated lung adenocarcinoma patients in the US and EU, and development of other new TKIs capable of inhibiting common resistance mutations is of high interest.