Other molecules able to interfere with TGF-β signaling that have been reported to block EndoMT in SSc include the inhibitor of the dipeptidyl peptidase-4 linagliptin [145,146] the major active constituent of licorice root glycyrrhizin, which ameliorated fibrosis, vasculopathy and inflammation in SSc animal models [147], and AdipoRon, a novel small molecule selective for adiponectin receptors that improved bleomycin-induced dermal fibrosis in mice by attenuating both fibroblast proliferation and EndoMT [148]. Here, DPP4 is linked to systemic sclerosis.