SEMA3E and systemic sclerosis: Finally, the antiangiogenic molecule semaphorin 3E, which has been found to contribute to defective angiogenesis of SSc dermal microvascular ECs and to participate in epithelial-to-mesenchymal transition, a transdifferentiation process similar to EndoMT, might have a possible role in SSc-associated EndoMT, as well [8,43,72].