CAV1 and systemic sclerosis: Interestingly, some molecules that are known to have a role in both SSc-related impaired angiogenesis and tissue fibrosis, namely vascular endothelial growth factor (VEGF)165b, soluble α-Klotho and caveolin-1 [64,65,66,67], have been correlated to the induction of EndoMT as well [54,68,69,70].