Accordingly, SSc dermal microvascular ECs undergoing EndoMT showed a significant Fli1 downregulation in culture [46] while ex vivo, mice with a conditional Fli1 deletion in ECs exhibited a significant downregulation of EC markers together with several vascular dysfunctions consistent with those detected in SSc microvasculature [56]. The gene discussed is FLI1; the disease is systemic sclerosis.