In the former, ET-1 and TGF-β stimulation was able to trigger EndoMT in SSc dermal microvascular ECs [53], while in the latter, microvascular ECs explanted from the unaffected skin of SSc patients were reported to transdifferentiate toward profibrotic myofibroblasts when co-cultured with SSc fibroblasts from affected skin and concomitantly treated with ET-1 and TGF-β [54]. This evidence concerns the gene EDN1 and systemic sclerosis.