TGFB1 and systemic sclerosis: Wnt/β-catenin, also known as canonical Wnt signaling, Notch, Hedgehog (Hh) and Hippo are all developmental signaling pathways mutually interconnected and orchestrated by TGF-β that are dysregulated in SSc and may contribute to myofibroblast accumulation and fibrosis [152,153,154].