A putative contribution in EndoMT induction has additionally been attributed, even if only in experimental scleroderma, to abnormal fibrillin-1 expression and chronic oxidative stress in the tight-skin mouse model of SSc [62] and to interferon regulatory factor 5 (IRF5), as demonstrated by the fact that EndoMT is inhibited in the IRF5 knockout mouse model [63]. The gene discussed is IRF5; the disease is scleroderma.