In the present study, cells derived from a control subject and an AMD patient were differentiated into RPE cells with appropriate RPE characteristics i.e., they displayed a pigmented and cobblestone-like morphology and expressed RPE-specific markers as well as exhibiting polarized secretion of PEDF and VEGF and a capability of undertaking in vitro phagocytosis of POS. Here, SERPINF1 is linked to age-related macular degeneration.