IL1B and age-related macular degeneration: Interestingly, IL1B expression was upregulated after MG-132 and bafilomycin A1 exposure only in control-RPE cells, but not in AMD-RPEs, a result which might explain why the increase in IL-1β levels in the media of AMD-RPE cells after MG-132 and bafilomycin A1 exposure remained non-significant (Figure 2B).