SOD2 and age-related macular degeneration: Previous studies on iPSC-RPE cells from AMD patients (hereafter referred to as AMD-RPE) and healthy controls (hereafter referred to as control-RPE) indicated that AMD-RPE cells displayed a reduced activity of the mitochondrial antioxidant enzyme superoxide dismutase 2 (SOD2) and had a higher susceptibility to oxidative stress [9,17,18,19].