Furthermore, the mRNA levels of SUGT1, which encodes ubiquitin ligase-associated protein suppressor of the G2 allele of SKP1 (SGT1), a protein that interacts with NLRP3 and Hsp90, were increased after the MG-132 and bafilomycin A1 exposure in both control-RPE and AMD-RPE. This evidence concerns the gene NLRP3 and age-related macular degeneration.