Additionally, many of the differences in mRNA expression levels that we observed between healthy donor-derived iPSC-RPE and AMD-RPE cells, i.e., increased IL-1β, interferon β (IFN-β), and Hsp90 mirrored previously reported changes in the RPE with AMD progression [28,41,43,56]. Here, HSP90AA1 is linked to age-related macular degeneration.