SOX2 and cancer: On the third day after CAAP irradiation, the cancer cells maintained a high level of transcription for some genes: HDAC2 (NOTCH signaling), ALPL and IGFR1 (osteogenic differentiation markers), SOX1 (self-renewal markers), ALDH1A1 and CD24 (cancer stem cells markers), SNAI1 (migration and metastasis markers), and for pluripotency markers (NANOG, POU5F1, and SOX2), the necrosis marker (CCDC103), and the pro-apoptotic factor TNFRSF1.