This regulation involves (i) polymorphisms in the promoter regions of MIOX gene [100], (ii) the activation of several transcription factors by different forms of stress induced by hyperglycemia [101], and (iii) post-translational modification of MIOX induced by kinases including protein kinase A and C and the 3-phosphoinositide-dependent protein kinase 1 [101]. Here, MIOX is linked to Hyperglycemia.