ACE inhibitors and the angiotensin receptor blockers (ARBs) have been established as a standard treatment for decades, (Bergamo Nephrologic Diabetes Complication Trial (BENEDICT) using the ACE inhibitor, trandolapril [17], Reduction of Endpoints in NIDDM with the Ang II Antagonist Losartan (RENAAL) [18], DETAIL (Diabetics Exposed to Telmisartan and Enalapril) using a drug combination [19]). The gene discussed is ACE; the disease is diabetes mellitus.