AK5 and acute myeloid leukemia: The three proteins that were significantly identified among three differential strategies included ANPEP (also known as CD13), MMP14, and AK5. ANPEP (CD13) as a potential target in AML is being investigated in a bispecific, and split CAR-T cells targeting CD13 and TIM3 as CD13 was shown to be overexpressed in AML cells [52].