Interestingly, several significant DEPs have shown to be of relevance to AML at the transcriptome level such as CRIP2. Overexpression of CRIP2 in CBF AML was previously reported to be highly overexpressed in leukemic stem cells (LSC) and is associated with chemotherapy resistance in AML in response to EZH2 inactivation [36]. This evidence concerns the gene CEBPZ and acute myeloid leukemia.