EZH2 and acute myeloid leukemia: Interestingly, several significant DEPs have shown to be of relevance to AML at the transcriptome level such as CRIP2. Overexpression of CRIP2 in CBF AML was previously reported to be highly overexpressed in leukemic stem cells (LSC) and is associated with chemotherapy resistance in AML in response to EZH2 inactivation [36].