Mothers against decapentaplegic homolog 4 (SMAD4), Neurofibromin 2 (NF2), Angiomotin Like 2 (AMOTL2), Forkhead box protein A2 (FOXA2), TEA Domain Transcription Factor 2 (TEAD2) and Yes-Associated protein 1 (YAP1) were selected for the targeted network and validated by several public certified databases to be related to Hippo signaling, cell differentiation/proliferation and NASH (Supplementary Figure S1). Here, SMAD4 is linked to metabolic dysfunction-associated steatohepatitis.