NF2 is a classic tumor suppressor, the loss of which is associated with multiple human tumor types and has been linked to over-proliferation caused by a number of signaling pathways [40].The conditional knock-out of Nf2 established by Benhamouche et al. [41] led to a reduction in Lats1/2 phosphorylation and thereby activation of YAP, resulting in hepatic overgrowth and liver tumor development. Here, YAP1 is linked to neoplasm.