Therefore, taken together, our experimental model hypothesized that Hippo signaling-targeted regulatory network (mRNAs YAP1, FOXA2, AMOTL2, TEAD2, SMAD4 and NF2)–miRNA (mir-650 and miR-1205)–lncRNA (RPARP-AS1 and SRD5A3-AS1) were significant differentially expressed between NAFLD and normal control and play important roles in disease pathogenesis (Figure 5). This evidence concerns the gene SRD5A3 and metabolic dysfunction-associated steatotic liver disease.