VEGFA and wet macular degeneration: Figure 4 shows a representative example of a patient with wet AMD with OCTs before (A) and after (B) the injection of an anti-VEGF agent with resolution of intraretinal and sub retinal fluid, where the treatment effect measured with contrast sensitivity is many times larger than the treatment effect measured with VA. Specifically, in this example, the improvement in VA (ΔVA) is only 0.1 LogMAR (1 line), from 0.40 LogMAR (20/50) to 0.30 LogMAR (20/40), yet the improvement in contrast sensitivity thresholds (Δcs) is many times larger, 0.46 LogCS at 3 cpd and 0.55 LogCS at 6 cpd. (Figure 4).