In contrast, in EGFR-mutated lung cancer cell lines expressing low levels of AXL (HCC827, HCC4006, and H3255 cells), EGFR TKI tolerance was mediated by an insulin-like growth factor-1 receptor (IGF-1R) through the induction of its transcription factor FOXA1 [44]. This evidence concerns the gene EGFR and lung carcinoma.