ITGB2 and lung carcinoma: Interestingly, European seabass (Dicentrarchus labrax) fed a plant-based diet showed a down-regulation in hepatic Integrin beta-2 compared to those fed a marine diet [95], while a reduction in the ω6:ω3 ratio of human lung cancer cells resulted in a delayed adhesion, and down-regulation of integrin-α2 [96].