KEAP1 and neurodegenerative disease: Keap1 (Kelch-like ECH-associated protein 1) is one of the adapter proteins in the Cul3-RING ubiquitin ligase complex and is well known because the Keap1-Nrf2 pathway has cell-protecting functions against various xenobiotic and oxidative stresses that result in neurodegenerative diseases and cancers [29].