Individual examination of the EZH2, SUZ12, and EED genes (Figure 2B–D) showed that CRPC and prostate neuroendocrine carcinoma demonstrated an association with frequent alterations in each of the PRC2 encoding genes, while in GCB-DLBCL lymphoma a high correlation was found only with alterations in the EZH2 gene. This evidence concerns the gene EZH2 and prostate neuroendocrine neoplasm.