INS and type 1 diabetes mellitus: Under 20 mM high glucose stimulation, iPSCs-derived islets generated from T1D patients showed insulin secretion similar to that of iPSCs-derived islets generated from non-diabetic patients, indicating glucose-dependent insulin secretion (2.0 ± 0.4 vs. 1.9 ± 0.3 mIU/103 cells) [42].