Bicuculline restored membrane expression of GLAST in hyperammonemic rats (107 ± 14% of controls, p < 0.01 with respect to hyperammonemia without bicuculline) but not those of GLT-1 (63 ± 10% of controls, p < 0.01) (Figure 6a,b). This evidence concerns the gene SLC1A3 and Hyperammonemia.