lncRNAs: A previous study found that a lncRNA recruited FUS/TLS (for translocated in liposarcoma) to the genomic locus encoding cyclin D1, where cyclin D1 transcription was inhibited in response to DNA damage signals, leading to an increased tolerance to cell apoptosis, which suggests that the destruction of FUS/TLS-induced single-stranded lncRNA may play a role in the pathological changes of neurodegenerative diseases [149,150]. The gene discussed is CCND1; the disease is neurodegenerative disease.