Taken together, regulation of proteins involved in APP and Aβ processing (NCSTN, APOE, CLU and RER1), microglial activity (C1QA-C, APOE, HEXB, PLD3, LAMP2, EPDR1, ERP29, RER1 and GLG1 and PLD3) and the endo-lysosome (PLD3, VTI1B, EPDR1, HEXB, ARL8B and LAMP2) in this APP/PS1 mouse model reflect multiple aspects of AD-related processes. This evidence concerns the gene PLD3 and Alzheimer disease.