SF3B1-mutated CLL patients present CD20 downregulation and, similarly to NOTCH1-mutated cells, they also present high levels of active intracytoplasmic Notch1 accompanied by a NOTCH1-related gene set enrichment and overexpression of a DVL2 isoform, involved in the Wnt pathway and Notch1 signaling repression [156,157]. The gene discussed is SF3B1; the disease is B-cell chronic lymphocytic leukemia.