Aykut et al. have reported that the connection of mannose-binding lectin (MBL), which attaches fungal wall glycans to enable the activation of the complement cascade, was responsible for neoplastic promotion, while MBL or C3 deletion in the extra-tumoral compartment or C3aR knockdown in cancer cells had been tumor-protective, even in the presence of Malassezia. Moreover, re-programming of the mycobiome has not changed PDA promotion in MBL or C3 deficient rodents. The gene discussed is C3; the disease is cancer.