Adipocyte-associated secretion of IL-6 also participates in the Notch/Wnt/TGF-β signaling pathways by upregulating ALDH1A1 [49] and LEF1 and AXIN2 gene expression in the Wnt pathway [50] to enhance the invasiveness, metastasis and angiogenesis of breast cancer. The gene discussed is ALDH1A1; the disease is breast cancer.