ASXL1 and cyclic hematopoiesis: This clonal hematopoiesis (CH) is defined as the presence of a somatic mutation associated with hematological malignancies such as DNMT3A, TET2, or ASXL1 (DTA mutations) without morphologic or clinical evidence of a hematological neoplasm, similar to the monoclonal gammopathy of undetermined significance (MGUS) [9] or monoclonal B-cell lymphocytosis (MBL).