SPINK4 and neoplasm: Table 2 reveals the correlations of SPINK4 immunoexpression with the clinicopathological variables. Low SPINK4 expression was remarkably linked with early pre-CCRT and post-CCRT tumor status (both p < 0.001), post-CCRT negative nodal status (p = 0.001), and less perineurial and vascular invasion (p = 0.023 and p = 0.015). Additionally, following CCRT treatment, low SPINK4 expression was remarkably linked with a greater level of tumor regression (p = 0.001).