There are also secondary genetic events that seem to be acquired for the progression of SMM to MM, including mutations in NRAS, KRAS, BRAF or NFKB pathways, loss-of-function of p53, PTEN or RB, and other genetic events, such as secondary translocations, miRNA changes and MYC upregulation [27]. This evidence concerns the gene BRAF and Miyoshi myopathy.