Progression of Alzheimer’s disease is associated with astroglial atrophy and cytoskeletal rearrangements that are confirmed morphologically and by analyzing the patterns of gene expression: significant decrease of mRNAs encoding for cytoskeletal proteins of myosin, kinesin families, actin, and integrins were detected in the advanced stage of Alzheimer’s disease [118]. This evidence concerns the gene MYH14 and early-onset autosomal dominant Alzheimer disease.