GFAP and early-onset autosomal dominant Alzheimer disease: Astrogliosis due to neuroinflammation is coupled with hypertrophy of astroglial cells and overexpression of GFAP [120], thus, high expression of GFAP (both GFAPα and GFAPδ) and presenilin (PS) (catalytic subunit of γ-secretase) was observed in astrocytes surrounding amyloid plagues in Alzheimer’s disease [121,122].