AKT1 and neoplasm: CUDC-101 (an inhibitor of epidermal growth factor receptor (EGFR), HER2, and histone deacetylase (HDAC)) inhibited tumor growth and metastases in metastatic ATC models [112], and lapatinib (an inhibitor of HER2 and EGFR) overcame the ERK and v-akt murine thymoma viral oncogene homolog 1 (AKT) rebound in PLX4032 resistant TC cells [113].