Several factors were claimed in order to explain the gender differences among COVID-19 patients especially those with severe disease; among these, the high expression of angiotensin-converting enzyme 2 in men than in women, sex hormones which could affect the inflammatory response but also the coagulation pattern, preexisting cardiovascular diseases as well as different lifestyle risk factors are those which could explain the observed gender imbalance in patients with COVID-19 [17,18]. This evidence concerns the gene ACE2 and cardiovascular disorder.