RNF213 and Moyamoya disease: The presence of the RNF213 c.14429G>A (p.Arg4810Lys, rs112735431) mutation in patients with moyamoya disease has been implicated in earlier onset, increased risk of cerebral infarction as an initial presentation, and more frequent posterior cerebral artery (PCA) involvement [22,23,24,25,26,27,28,29].