These sarcoma cells express both the collagenolytic protease membrane type 1-matrix metalloproteinase (MT1-MMP/MMP14) and the endocytic collagen receptor, urokinase plasminogen activator receptor-associated protein (uPARAP/Endo180), two membrane-associated proteins with established roles in bone remodeling [78]. The gene discussed is MMP14; the disease is sarcoma.