Based on the evidence of subclinical myocardial damage produced by prediabetes (see Section 6.1, a recent article hypothesizes that sodium-glucose cotransporter-2 (SGLT-2) inhibitors administered in the prediabetic state might play a role in the prevention of heart failure (mainly HFpEF) in patients with diabetes mellitus [129]. The gene discussed is SLC5A2; the disease is prediabetes syndrome.