LCN2 and colonic neoplasm: Even in the same genetic origin, increasing LCN2 expression in poorly metastatic human colon cancer (KM12C) cells generates more invasive abilities while LCN2 short hairpin RNA has the opposite effect; nevertheless, over-expressing LCN2 in the highly metastatic human colon cancer (KM12SM) cell line greatly reduces its invasive behavior in vitro and in vivo [23].