CXCL1 and Familial prostate cancer: In prostate cancer cells, LCN2 plays an important role in facilitating cell migration and invasion of prostate cancer by inducing EMT through the ERK/SLUG axis [36], and the CXCL1-LCN2 axis triggers a cascade amplification event of Src signaling, EMT, and migration, leading to promotion of cancer metastasis [37].