LCN2 and colorectal cancer: Furthermore, LCN2 promotes EMT through Rac1, one of Ras homolog gene family (Rho) small guanosine triphosphate hydrolases (GTPases) and an integral regulator of EMT induction, to increase KM12C cell motility and invasion, indicating that LCN2 may be a target for therapeutic intervention in colorectal cancer cell metastasis [39].